Pathophysiological concepts of restless legs syndrome
Identifieur interne : 002C84 ( Main/Exploration ); précédent : 002C83; suivant : 002C85Pathophysiological concepts of restless legs syndrome
Auteurs : Walter Paulus [Allemagne] ; Pascal Dowling [Allemagne] ; Roselyne Rijsman [Pays-Bas] ; Karin Stiasny-Kolster [Allemagne] ; Claudia Trenkwalder [Allemagne] ; Al De Weerd [Pays-Bas]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-07-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Corpus Striatum (metabolism), Corpus Striatum (pathology), Diagnostic Imaging (methods), Dopamine, Dopamine (metabolism), Humans, Nervous system diseases, Opiates, Pathophysiology, Restless Legs Syndrome (pathology), Restless Legs Syndrome (physiopathology), Restless legs syndrome, dopamine, opiate, pathophysiology, restless legs, spinal.
- MESH :
- chemical , metabolism : Dopamine.
- metabolism : Corpus Striatum.
- methods : Diagnostic Imaging.
- pathology : Corpus Striatum, Restless Legs Syndrome.
- physiopathology : Restless Legs Syndrome.
- Humans.
Abstract
Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data. Furthermore treatment effects contribute essentially to the present understanding of the disease, unless the genetic progress expected in the near future will clarify substantially open issues. The concept agreed on assumes a dysfunction of the dopaminergic system, possibly on the level of striatal and/or spinal dopamine receptors, and the A11 neuron group localized in the hypothalamus as an integrated part of the system. These neurons modulate spinal excitability, alterations of which in turn affect sensory processing predominantly of leg afferents in brain stem structures. Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H‐reflex testing, and quantitative sensory testing. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21533
Affiliations:
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Le document en format XML
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MCHaaglanden, Westeinde Hospital, The Hague</wicri:regionArea><wicri:noRegion>The Hague</wicri:noRegion></affiliation></author><author><name sortKey="Stiasny Olster, Karin" sort="Stiasny Olster, Karin" uniqKey="Stiasny Olster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Philipps University of Marburg</wicri:regionArea><wicri:noRegion>Philipps University of Marburg</wicri:noRegion><wicri:noRegion>Philipps University of Marburg</wicri:noRegion></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus Elena Klinik, Centre of Parkinsonism and Movement Disorders, Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Sleepcenter and Department of Clinical Neurophysiology, SEIN Zwolle, Zwolle</wicri:regionArea><wicri:noRegion>Zwolle</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-07-30">2007-07-30</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1451">1451</biblScope><biblScope unit="page" to="1456">1456</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">6719F1AC8FF041437899AE0C7B5CBCA794B9DF99</idno><idno type="DOI">10.1002/mds.21533</idno><idno type="ArticleID">MDS21533</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corpus Striatum (metabolism)</term><term>Corpus Striatum (pathology)</term><term>Diagnostic Imaging (methods)</term><term>Dopamine</term><term>Dopamine (metabolism)</term><term>Humans</term><term>Nervous system diseases</term><term>Opiates</term><term>Pathophysiology</term><term>Restless Legs Syndrome (pathology)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Restless legs syndrome</term><term>dopamine</term><term>opiate</term><term>pathophysiology</term><term>restless legs</term><term>spinal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diagnostic Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Corpus Striatum</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Impatience membre inférieur syndrome</term><term>Opiacés</term><term>Physiopathologie</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pathophysiological concepts of restless legs syndrome (RLS) are based mainly on neuroimaging and on neurophysiological data. Furthermore treatment effects contribute essentially to the present understanding of the disease, unless the genetic progress expected in the near future will clarify substantially open issues. The concept agreed on assumes a dysfunction of the dopaminergic system, possibly on the level of striatal and/or spinal dopamine receptors, and the A11 neuron group localized in the hypothalamus as an integrated part of the system. These neurons modulate spinal excitability, alterations of which in turn affect sensory processing predominantly of leg afferents in brain stem structures. Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H‐reflex testing, and quantitative sensory testing. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Pays-Bas</li></country><region><li>Basse-Saxe</li><li>District de Kassel</li><li>Hesse (Land)</li></region><settlement><li>Cassel (Hesse)</li><li>Göttingen</li></settlement></list><tree><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Paulus, Walter" sort="Paulus, Walter" uniqKey="Paulus W" first="Walter" last="Paulus">Walter Paulus</name></region><name sortKey="Dowling, Pascal" sort="Dowling, Pascal" uniqKey="Dowling P" first="Pascal" last="Dowling">Pascal Dowling</name><name sortKey="Stiasny Olster, Karin" sort="Stiasny Olster, Karin" uniqKey="Stiasny Olster K" first="Karin" last="Stiasny-Kolster">Karin Stiasny-Kolster</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></country><country name="Pays-Bas"><noRegion><name sortKey="Rijsman, Roselyne" sort="Rijsman, Roselyne" uniqKey="Rijsman R" first="Roselyne" last="Rijsman">Roselyne Rijsman</name></noRegion><name sortKey="De Weerd, Al" sort="De Weerd, Al" uniqKey="De Weerd A" first="Al" last="De Weerd">Al De Weerd</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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